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Pediatric Combo Vaccine Linked To Slight Risk Of Febrile Seizure
A study, published in JAMA of almost 400,000 children, showed that children had an increased risk of febrile seizures, a convulsion that occurs secondary to a rapid increase in body temperature on the day of the first and second vaccination, with the combined diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus - Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. However, the overall risk was low, with researchers observing no higher risk of epilepsy in those who were vaccinated, compared with those who were not... (Source: Health News from Medical News Today)

Tomato, black bean soup's on and it's sure to satisfy
There's a reason that easy, healthful, satisfying soups are a reliable standard for busy winter weeknight meals. (Source: USATODAY.com Health)

Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice [Articles]

The experiments described herein compared the extent of in vivo P-glycoprotein (P-gp)-mediated brain efflux between rats and mice for a set of known central nervous system compounds. With use of newly introduced genetically modified mdr1a-deficient rats and their gene-competent counterparts, the brain to plasma distribution was assessed and compared with the distribution pattern in mdr1a-deficient and wild-type mice. Four compounds (aripiprazole, citalopram, risperidone, and venlafaxine) were administered using a continuous subcutaneous osmotic minipump infusion paradigm. Steady-state brain and plasma concentrations of the compounds, including selected metabolites (9-hydroxyrisperidone, O-desmethyl-venlafaxine and N-desmethyl-venlafaxine) were measured in mdr1a-deficient rats and mice and their wild-type counterparts along with their free fractions to determine total and unbound brain to plasma distribution between genotypes within and between species. The results revealed qualitative as well as quantitative similarities between P-gp functionality in vivo at the blood-brain barrier level in rats and mice. All compounds tested were shown to have a significantly higher brain to plasma distribution in both mdr1a-deficient rats and mice compared with that in their wild-type counterparts. Moreover, the relative enhancement in extent of brain penetration between mdr1a-deficient and wild-type rats could be directly correlated to the enhancement ratios obtained in mice. From the unbound brain to unbound plasma distributions, the impact of P-gp on the overall brain penetration capabilities showed minor differences between rats and mice for the compounds tested. In conclusion, a comparable functional role of P-gp between rats and mice with respect to brain efflux mediated by this transporter is suggested.

Low Febrile Seizure Risk After Acellular Pertussis VaccineLow Febrile Seizure Risk After Acellular Pertussis Vaccine
The risk for febrile seizure increases after administration of the acellular pertussis vaccine, but the absolute risk remains small, and vaccination does not raise the risk of epilepsy. Medscape Medical News (Source: Medscape Today Headlines)

British youth don't know alcohol limits
FALMER, England, Feb. 22 (UPI) -- Young people ages 14-22 in Britain do not possess the knowledge or skills to adhere to government guidelines for responsible drinking, researchers found. (Source: Health News - UPI.com)

Malaria drug may help boost cancer therapy
VANCOUVER, British Columbia, Feb. 21 (UPI) -- Blocking autophagy -- the process of "self-eating" within cells -- might be a viable way to enhance cancer treatment effectiveness, U.S. researchers said. (Source: Health News - UPI.com)

FDA approves BioSante/Teva's testosterone gel (Reuters)
Reuters - U.S. drug regulators approved a new testosterone gel from BioSante Pharmaceutical Inc and Teva Pharmaceuticals, a Food and Drug Administration spokeswoman said.